Method for the purification of parasite antigenic factors

Details Method for the purification of parasite antigenic factors Method for the purification of parasite antigenic factors

1984-04-16

1989-08-22

Wiseman, Thomas G.

Drug, bio-affecting and body treating compositions

Lymphokine

435 68, 435 70, 514 2, 514 8, 530350, 530359, 530395, 530402, 530822, 530419, 530421, 530422, 530423, 530426, C12P 2100, A61K 3900, A61K 3700

Patent

active

048594644

ABSTRACT:
A method for the solubilization and recovery of insoluble parasite protective antigenic factors associated with parasite material comprising solubilizing the antigenic factors with a non-ionic detergent and separating the solubilized material from undispersed residual material. The purified protective antigenic factors are useful as vaccines, particularly against malaria, and as diagnostic agents.

REFERENCES:
Grothhaus et al Infec and Immun Apr. 1980, vol. 28(1) pp. 245-233 "Isolation of a Souble Component of Plasmodium berghei which induces immunity in rats".
Kilejian Proc. Natl Acad Sci vol. 77(6) Jun. 1980 pp. 3695-3699 "Stage-specific proteins and glycoproteins of Plasmodium Falciparum: Identification of antigens unique to schizonts and merozoites".
D'Antonio et al Science vol. 168 pp. 1117-1118 1970.
D'Antonio et al Exptl Parasitology vol 31 pp. 75-81 1972.
D'Antonio et al Immunolgy Serolog Aspects of Clin Parasitology p. 59 1981.
Miller Biochem Biophys Res Comm vol. 40 (3) 1970 "Total Solubilization of erythrocyte membranes by non-ionic detergents".
Ludford et al Exp Parasit vol. 32 pp. 317-326 1972.
Cox et al Amer J Trop Med Hygiene vol. 17 (2) 1968 pp. 173-179.

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