Method for selection of antigens suitable as in vivo targets for

Details Method for selection of antigens suitable as in vivo targets for Method for selection of antigens suitable as in vivo targets for

1986-09-11

1989-01-17

Maples, John S.

Drug, bio-affecting and body treating compositions

Radionuclide or intended radionuclide containing; adjuvant...

436547, 436548, 424 9, A61K 4902, G01N 3353

Patent

active

047987197

ABSTRACT:
The present invention is a process for the selection of antigens which are suitable targets for in vivo antibody localization in tumors or other altered (or diseased) tissue. The process provides a simplified and rapid technique for discovering useful in vivo targets for antibodies and is useful in cancer detection and therapy in humans or animals, whether or not the antigens are specific to tumors.
More specifically, the invention relates to a process for the selection of antigens suitable as targets for antibodies which localize in tumors in animals in vivo comprising preparing antibodies distinguishable from those present in the animal in which tumor targeting is to occur and that bind to antigens present in the tumor in said animal; injecting the prepared antibodies into a non-tumor-bearing animal to permit biofiltration of the antibodies; recovering the biofiltered antibodies from the non-tumor-bearing animal; employing the recovered biofiltered antibodies to identify antigens whose antibodies are not retained in vivo in the animal; and screening the antibodies that are not retained in vivo by the non-tumor bearing animal both to determine those antibodies that are actually retained in vivo in the tumor-bearing animal and to identify the antigens corresponding to those antibodies retained in the tumor-bearing animal.

REFERENCES:
patent: 4065552 (1977-12-01), Costa
patent: 4279884 (1981-07-01), Bradwell et al.
patent: 4446122 (1984-05-01), Chu et al.
patent: 4448890 (1984-05-01), Smetana et al.
patent: 4610869 (1986-09-01), Bogden

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