Method for improving the glutamine content in skeletal muscle an

Details Method for improving the glutamine content in skeletal muscle an Method for improving the glutamine content in skeletal muscle an

1992-06-11

1994-05-10

Waddell, Frederick E.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Radical -xh acid, or anhydride, acid halide or salt thereof...

514557, 514561, A61K 3119, A61K 31195

Patent

active

053107683

ABSTRACT:
A method of treatment of postoperative and posttraumatic patients for improving the glutamine content in skeletal muscle by administrating alpha-ketoglutarate; also, a composition for carrying out the method.

REFERENCES:
patent: 3542929 (1970-11-01), Roberts
patent: 4663166 (1987-05-01), Veech
patent: 4929449 (1990-05-01), Veech
patent: 5100677 (1992-03-01), Veech
Hammerqvist, F., et al., "Alpha-ketoglutarate preserves protein synthesis and free glutamine in skeletal muscle after surgery", Surgery (1991), vol. 109, pp. 28-36.
Wernerman, J., et al., "Alpha-ketoglutarate and postoperative muscle catabolism", The Lancet (1990), vol. 335, pp. 701-703.
Dialog 05710808, Medline 86011808, "Changes in protein metabolism in cachexia and catabolism" (1985).
The Merk Index, 10th Edition (1983), p. 762, cite #5140.

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