Process for the preparation of HMG-CoA reductase inhibitors inte

Details Process for the preparation of HMG-CoA reductase inhibitors inte Process for the preparation of HMG-CoA reductase inhibitors inte

1987-09-18

1989-08-22

Killos, Paul J.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acid esters

560 60, 560119, 568592, C07C 6974

Patent

active

RE0330337

ABSTRACT:
hypercholesterolemic compounds of the HMG-CoA reductase type of the following general formula (1): ##STR1## involving an enantioselective aldol condensation is disclosed.

REFERENCES:
patent: 4137322 (1979-01-01), Endo et al.
patent: 4346227 (1982-08-01), Terahara et al.
patent: 4375475 (1983-03-01), Willard et al.
patent: 4438277 (1984-03-01), Terahara et al.
patent: 4444784 (1984-04-01), Hoffman
patent: 4447626 (1984-05-01), Teroharu et al.
J. E. Lynch, Tetrahedron Letters, 28, No. 13, 1385, (1987).
M. Braun, Angew. Chem. Int. Ed., Engl., 26, 24, (1987).

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