Reagents for enantioselective acylation and related reactions

Details Reagents for enantioselective acylation and related reactions Reagents for enantioselective acylation and related reactions

1995-05-17

1997-07-08

Ivy, C. Warren

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

544124, 544360, 546193, 5462764, C07D21330

Patent

active

056462875

ABSTRACT:
The invention provides a method for synthesizing chiral compounds utilizing novel catalysts which are enantioselective electrophiles via kinetic resolution. The method includes treating a racemic mixture with a reagent which is a chiral DMAP derivative, a chloroformate, a trialkylamine and a Lewis acid to preferentially form a product of one of the enantiomer pair of the mixture. The invention also provides a method for resolving racemic mixture via parallel kinetic resolution.

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Weidmann et al., Bulletin de la Societe Chimique de France, (1967) No. 1, pp. 117-124.

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