E-selection binding soluble lamp-1 polypeptide

Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

435 691, 536235, C07K 14435, C12N 1512

Patent

active

056462484

ABSTRACT:
The present invention provides novel purified human lysosomal membrane sialoglycoproteins. These novel human proteins, lamp-1 and lamp-2, are highly glycosylated and are the major carriers of polylactosaminoglycan, when expressed on the cell surface participate in various cellular adhesion interactions.

REFERENCES:
Sueyoshi et al., J. Biol. Chem., vol. 269, pp. 32342-32350, 1994.
Carlsson, Sven R. and Fukuda, Minoru. "The Lysosomal Membrane Glycoprotein Lamp-1 is Transported to Lysosomes by Two Alternative Pathways." Archives of Biochem. and Biophysics. 296:630-639 (1992).
Sawada, R, Tsuko et al., "The Genes of Major Lysosomal Membrane Glycoproteins, Lamp-1 and Lamp-2." J. Biol. Chem. 268:9014-9022 (1993).
Fukuda, Minoru et al., "Cloning of cDNAs Encoding Human Lysosomal Membrane Glycoproteins, H-Lamp-1 and h-lamp-2." J. Biol. Chem. 263:18920-18298 (1988).
Carlsson, Sven R. et al., "Isolation and Characterization of Human Lysosomal Membrane Glycoproteins, h-lamp-1 and h-lamp-2." J. Biol. Chem. 263:18911-18919 (1988).
Lasky, Laurence A. et al., "An Endothelial Ligand for L-Selection Is A Novel Mucin-like Molecule." Cell. 69:927-938 (1992).
Lowe, John B. et al., "ELAM-1-Dependent Cell Adhesion to Vascular Endothelium Determined by a Transfected Human Fucosyltranzferase cDNA." Cell. 63:475-484 (1990).
Mane, Shrikant M. et al., "Purification of Characterization of Human Lysosmal Membrand Glycoproteins." Archives of Biochemistry and Biophysics. 268:360-378 (1989).
Harter, Cordula and Mellman, Ira "Transport of the Lysosomal Membrane Glycoprotein lgp120 (lgp-A) to Lysosomes Does Not Require Appearance on the Plasma Membrane." J. Cell Biology 117:311-325 (1992).
Saitoh, Osamu et al., "Diffential Glycosylation and Cell Surface Expression of Lysosomal Membrane Glycoproteins in Sublines of a Human Colon Cancer Exhibiting Distincy Metastatic Potentials." J. Biol. Chem. 267:5700-5711 (1992).
Lee, Ni et al., "Granulocytic Differentiation of HL-60 Cells is Associated with Increase of Poly-N-acetyllactosamine in Asn-linked Oligosacchrides Attached to Human Lysosomal Membrane Glycoproteins." J. Biol. Chem. 265:20476-20487 (1990).
Springer, Timothy A. "Adhesion Receptors of the Immune System." Nature. 346:425-434 (1990).
Kuijpers, Taco W. et al., "CD66 Nonspecific Cross-reacting Antigens Are Involved in Neutrophil Adherence to Cytokine-activitated Endothelial Cells." J. Cell. Biol. 118:457-466 (1992).
Lawrence, Michael B. et al., "Leukocytes Roll on a Selectin at Physiologic Flow Rates: Distinction from and Prerequisite for Adhesion through Integrins." Cell 65:859-873 (1991).
Polley, Margaret J. et al., "CD62 and Endothelial cell-leukocyte Adhesion Molecule 1 (ELAM-1) Recognize the Same Carbohydrate Ligand, Sialyl-Lewis x." Proc. Natl. Acad. Sci. USA. 88:6224-6228 (1991).
Viitala, Juha et al., "Molecular Cloning of cDNAs Encoding Lamp A, a human Lysosomal Membrane Glycoprotein with Apparent M.sub.r .apprxeq.120,000." Proc. Natl. Acad. Sci. USA 85:3743-3747 (1988).
Yamashita, Katsuko et al., "Carbohydrate Structures of Nonspecific Cross-reacting Antigen-2, a Clycoprotein Purified from Meconium as an Antigen Cross-reacting with Anticarcinoembryonic Antigen Antibody." J. Biol. Chem. 264:17873-17881 (1989).
Mulligan, Michael S. et al., "Role of Endothelial-Leukocyte Adhesion Molecule 1 (ELAM-1) in Neutrophil-mediated Lung Injury in Rats." J. Clin. Invest. 88:1396-1406 (1991).
Ley, Klaus et al., "Lectin-Like Cell Adhesion Molecule 1 Mediates Leukocyte Rolling in Mesenteric Venules in Vivo." Blood 77:2553-2555 (1991).
Lippincott-Schwartz, Jennifer et al., "Cycling of the Integral Membrane Glycoprotein LEP100, between Plasma Membrane and Lysosomes: Kinetic an Morphological Analysis." Cell 49:669-677 (1987.
Williams, Mark A. and Fukuda, Minoru, "Accumulation of Membrane Glycoproteins in Lysosomes Requires a Tyrosine Residue at a Particular Position in the Cytoplasmic Tail." J. Cell Biology. 111:955-966 (1990).
Kim, Young S. et al., "Le.sup.x and Le.sup.y Antigen Expression in Human Pancreatic Cancer." Cancer Res. 48:475-482 (1988).
Carlsson, Sven R. and Fukuda, Minoru. "Structure of Human Lysosomal Membrane Glycoprotein 1." J. Biol. Chem. 264:20526-20531 (1989).
Fukuda, Michiko N. et al., "Structures of Glycosphingolipids Isolated from Human Granulocytes." J. Biol. Chem. 260:1067-1082 (1985).
Mathews, Paul M. et al., "The Pathway and Targeting Signal for Delivery of the Integral Membrane Glycoprotein LEP100 to Lysosomes." J. Cell Biology. 118:1027-1040 (1992).
Mizoguchi, Akira et al., "Changes in Asparagine-linked Sugar Chains of Human Promyelocytic Leukemic Cells (HL-60) during Monocytoid Differentiation and Myeloid Differentiation." J. Biol. Chem. 259:11949-11957 (1984).
Maemura, Kentaro and Fukuda, Minoru "Poly-N-acetyllactosaminyl o-Glycans Attached to Leukosialin." J. Biol. Chem. 267:24379-24386 (1992).
Fukushima, Kiyoyasu et al., "Characterization of Sialosylated Lewis.sup.x as a New Tumor-associated Antigen." Cancer Res. 44:5279-5285 (1984).
Kameyama, Akihiko et al., "Total Synthesis of Sialyl Lewis X*." Carbohy. Res. 209:C1-C4 (1991).
Laferte, Suzanne and Dennis, James W. "Purification of Two Glycoproteins Expressing .beta.1-6 Branched Asn-Linked Oligosaccharides from Metastatic Tumour Cells." Biochem J. 259:569-576 (1989).
Moore, Kevin L. et al., "Identification of Specific Glycoprotein Ligand for P-selection (CD62) on Myeloid Cells." J. Cell Biol. 118:445-456 (1992).
Phillips, M. Laurie, et al., "ELAM-1 Mediates Cell Adhesion by Recognition of a Carbohydrate Ligand. Sialyl-Le.sup.x." Science. 250:1130-1131 (1990).
Walz, Gerd, et al., "Recognitiion by ELAM-1 of the Sialyl-Le.sup.x Determinant of Myeloid and Tumor Cells." Science. 250:1132-1135 (1990).
Picker, Louis J. et al., "The Neutrophil Selection LECAM-1 Presents Carbohydrates Ligands to the Vascular Selectins ELAM-1 and GMP-140." Cell 66:921-933 (1991).
Larsen, Eric et al., "PADGEM-Dependent Adhesion of Platelets to Monocytes and Neutrophils is Mediated by a Lineage-Specific Carbohydrate, LNF III (CD15)." Cell 63:467-474 (1990).
Magnani, John L. et al., "A Monoclonal Antibody-defined Anitgen Associated with Gastrointestinal Cancer is a Ganglioside Containing Siaylylated Lacto-N-fucopentaose II." J. Biol. Chem. 257:14365-14369 (1992).
Holmes, Eric H. et al., "Biosynthesis of the Sialyl-Le.sup.x Determinant Carried by Type 2 Chain Glycosphingolipids (IV.sup.3 NeuAcIII.sup.3 FucnLc.sub.4, VI.sup.3 NeuAcV.sup.3 FucnLc.sup.6, and VI.sup.3 NeuAcIII.sup.3 V.sup.3 Fuc.sub.2 Lc.sub.6) in Human Lung Carcinoma PC9 Cells." J. Biol. Chem. 261:3737-3743 (1986).
Berg, Ellen L. et al., "A Carbohydrate Domain Common to Both Sialyl Le.sup.a and Sialyl Le.sup.x is Recognized by the Endothelial Cell Leukocyte Adhesion Molecule ELAM-1." J. Biol. Chem. 266:14869-14872 (1991) .

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

E-selection binding soluble lamp-1 polypeptide does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with E-selection binding soluble lamp-1 polypeptide, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and E-selection binding soluble lamp-1 polypeptide will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-2409410

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.