Phenyl amidine alkanoic acids useful as platelet aggregation inh

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Ester doai

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514539, 562440, 560 35, A01N 3736, C07C22942

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active

056461836

ABSTRACT:
This invention relates to phenyl amidine alkanoic acids and lactones having the following formula ##STR1## or a pharmaceutically acceptable salt which are useful in the inhibition of platelet aggregation. This invention also relates to pharmaceutical compositions of such phenyl amidine derivatives.

REFERENCES:
patent: 4517686 (1985-05-01), Ruoslahti et al.
patent: 4578079 (1986-03-01), Ruoslahti et al.
patent: 4589881 (1986-05-01), Pierschbacher et al.
patent: 4614517 (1986-09-01), Ruoslahti et al.
patent: 4661111 (1987-04-01), Ruoslahti et al.
patent: 4683291 (1987-07-01), Zimmerman et al.
patent: 4791102 (1988-12-01), Bernat et al.
patent: 4857508 (1989-08-01), Adams et al.
patent: 4879313 (1989-11-01), Tjoeng et al.
patent: 4977168 (1990-12-01), Bernat et al.
patent: 5220050 (1993-06-01), Bovy et al.
M. Kloczewiak et al. "Platelet Receptor Site on Human Fibrinogen" Biochemistry, 23(8), pp. 1767-1774. Jan. 1984.
Z. Ruggeri et al. "Inhibition of platelet function with synthetic peptides designed to be high-affinity antagonists of fibrinogen binding to platelets" Proc. Natl. Acad. Sci. USA. 83, pp. 5708-5712. Aug. 1986.
E. Plow et al. "The Effect of ARG-GLY-ASP-containing peptides on fibrinogen and von Willebrand factor binding to platelets" Proc. Natl. Acad. Sci. USA. 82, pp. 8057-8061. Dec. 1985.
M. Ginsberg et al. "Inhibition of Fibronectin Binding to Platelets by Proteolytic Fragments and Synthetic Peptides Which Support Fibroblast Adhesion*", The Journal of Biological Chemistry, 260(7), pp. 3931-3936. Apr. 1985.
D. Haverstick et al. "Inhibition of Platelet Adhesion to Fibronectin, Fibrinogen, and von Willebrand Factor Substrates by a Synthetic Tetrapeptide Derived From the Cell-Binding Domain of Fibronectin" , Blood 66(4), pp. 946-952. Oct. 1985.
E. Ruoslahti et al. "New Perspectives in Cell Adhesion: RGD and Integrins" Science, 23, pp. 491-497. Oct. 1987.
P. Walsmann et al. "Synthetic Inhibitors of Serine Proteinases" Pharmazie. 29(5), pp. 333-336. Jan. 1974.

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