Method for administering surfactant to the lungs while concurren

Surgery – Respiratory method or device – Means for mixing treating agent with respiratory gas

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12820714, 604 28, 604 49, 604 54, 604 56, A61M 1500, A61M 1610, A62B 906

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active

053099036

ABSTRACT:
A method of administering a liquid pharmaceutical formulation, particularly a surfactant formulation, to at least one lung of a subject in need of such treatment is disclosed. The method is carried out while the subject has a breathing tube extending through the subject's mouth and larynx, and while ventilating at least one lung of the subject through the breathing tube. The method comprises simultaneously administering the liquid pharmaceutical formulation down the breathing tube and into at least one lung of the subject and ventilating at least one lung of the subject through the breathing tube. The method may be performed on premature infants to combat respiratory distress syndrome. A preferred apparatus for carrying out the method of the present invention comprises a breathing tube configured for insertion through a subject's mouth and larynx, a ventilating apparatus operatively associated with the breathing tube, and an injecting device such as a syringe operatively associated with the breathing tube for introducing a liquid pharmaceutical formulation into the breathing tube.

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patent: 5207220 (1993-05-01), Long
M. Hallman et al., Pediatrics 71, No. 4, 473-482 (1983).
G. Enhorning et al., Pediatrics 76, No. 2, 145-153 (1985).
A. Wilkinson et al., The Lancet Ltd., 287-291 (Aug. 10, 1985).
T. Des Jardins, in Clinical Manifestations of Respiratory Disease, (Year Book Medical Publishers, Inc.) pp. 312-326 (1984).
"Product Monograph. Synthetic Lung Surfactant for the Treatment of Neonatal Respiratory Distress." Publication by Burroughs Wellcome Co. (1990).

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