Process for the in-solvent, in-situ generation of haloalkyl alky

Details Process for the in-solvent, in-situ generation of haloalkyl alky Process for the in-solvent, in-situ generation of haloalkyl alky

1981-02-03

1983-02-01

Helfin, Bernard

Organic compounds -- part of the class 532-570 series

Organic compounds

Oxygen containing

568669, 568676, 568686, 549427, 549504, 549511, C07C 4101

Patent

active

043717179

ABSTRACT:
The present invention is directed to a process for the preparation of certain N-substituted-2-haloacetanilides via the reaction of a secondary 2-haloacetanilide with a haloalkyl ether, particularly, halomethyl ethers, which comprises forming the ether in situ by the in-solvent reaction of an alcohol, formaldehyde or other aldehyde and an acid halide to produce high purity haloalkyl ethers, while decreasing the concentration of undesirable bis by products, as for example bis(chloromethyl) ether. The ether formed in situ thereafter reacts with the secondary 2-haloacetanilide in the presence of a phase transfer catalyst and base to form the N-substituted-2-haloacetanilide.

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