Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Parasitic organism or component thereof or substance...
Patent
1980-08-22
1983-02-01
Jiles, Henry R.
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Parasitic organism or component thereof or substance...
548338, A61K 31415
Patent
active
043715400
ABSTRACT:
Two compounds represented by the formula ##STR1## wherein R is hydrogen or a 2-hydroxyethyl radical are reported to have minimum penetration into the brain and nerve tissues combined with maximum penetration into hypoxic tumor cells. This combination of properties makes these compounds the optimal radiosensitizers among electron-affinic 1-substituted 2-nitroinidazoles.
REFERENCES:
patent: 3679698 (1972-07-01), Beaman et al.
Asquith et al., Radiation Research 1974, vol. 60, pp. 108-118.
Hall et al., British Journal of Cancer 1978, vol. 37, Suppl. III, pp. 120-123.
Dische et al., British Journal of Cancer 1977, vol. 35, pp. 567-579.
Brown et al., Radiation Research 1980, vol. 82, pp. 171-190.
Brown J. Martin
Cory Michael J.
Lee William W.
Martinez Abelardo P.
Harkaway N.
Jiles Henry R.
The United States of America as represented by the Secretary of
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