Chemistry of carbon compounds – Miscellaneous organic carbon compounds – C-metal
Patent
1981-03-16
1983-02-01
Berch, Mark L.
Chemistry of carbon compounds
Miscellaneous organic carbon compounds
C-metal
2602444, 2602456, 2603303, C07D24316, C07D48704, C07D40104, C07D48714
Patent
active
043714684
ABSTRACT:
Novel imidazobenzodiazepines and their analogs are useful as anticonvulsants, muscle relaxant, anxiolytic and sedative agents. Preferred compounds of this class belong to the imidazo[1,5-a][1,4]diazepine series which may have a very wide variety of organic substituents. As especially preferred genus included within the purview of the invention encompasses a compound of the formula ##STR1## wherein R.sub.1 is hydrogen and lower alkyl, preferably methyl; R.sub.3 and R.sub.5 are hydrogen; R.sub.4 is hydrogen, nitro and halogen, most preferably chlorine, and in a most preferred embodiment when positioned on the fused benzo portion of the imidazobenzodiazepine is in the 8-position thereof. R.sub.6 is phenyl or halo, nitro, or lower alkyl-substituted phenyl, preferably halo, with fluorine being the preferred halogen, the substituted fluoro being positioned in the 2-position of the phenyl moiety and R.sub.2 is hydrogen and lower alkyl.
REFERENCES:
patent: 3825533 (1974-07-01), Nudelman
patent: 3998809 (1976-12-01), Milkowski et al.
patent: 4170649 (1979-10-01), Liepmann
Hoffmann-La Roche, Chem. Abs. 83, 28295n (1974).
McCaully, Chem. Abs. 78, 16243c (1973).
Fryer Rodney I.
Walser Armin
Berch Mark L.
Hoffman Frank P.
Hoffmann-La Roche Inc.
Leon Bernard S.
Saxe Jon S.
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