Methods of controlling mycoplasma infections

Details Methods of controlling mycoplasma infections Methods of controlling mycoplasma infections

1985-02-27

1986-06-10

Goldberg, Jerome D.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

A61K 3170

Patent

active

045943370

ABSTRACT:
Methods of controlling Mycoplasma infections which comprise administering to an infected or susceptible warm-blooded animal an effective amount of a new macrocin or lactenocin ester derivative of the formula: ##STR1## wherein R is formyl or hydroxymethyl; R.sup.1 is hydrogen, acetyl or propionyl; R.sup.2 is hydrogen or ##STR2## and R.sup.3 is hydrogen, acetyl, propionyl, n-butyryl or isovaleryl; provided that one of R.sup.1 or R.sup.3 must be other than hydrogen; or a pharmaceutically acceptable acid addition salts thereof.

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patent: 4341770 (1982-07-01), Ose et al.
patent: 4379781 (1983-04-01), Hull et al.
Derwent Abstract No. 03335B/62 of Japanese Unexamined Patent J5 3137-982, 12-1-78, (Sanraku Ocean).
Okamoto et al., "The Activity of 4"-Acylated Tylosin Derivatives Against Macrolide-Resistant Gram-Positive Bacteria", J. Antibiotics 32, 542-544, (1979).
Okamoto et al., "Biological Properties of New Acyl Derivatives of Tylosin", J. Antibiotics 33, 1309-1315, (1980).
Tsuchiya et al., "Studies of Tylosin Derivatives Effective Against Macrolide-Resistant Strains: Synthesis and Structure Activity Relationships", J. Antibiotics 35, 661-672, (1982).
Kirst et al., "Structure-Activity Studies Among 16-Membered Macrolide Antibiotics Related to Tylosin", J. Antibiotics 35 (12), 1675-1682, (1982).

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