Thiolated polypeptide compound derived from a tetanus toxin frag

Details Thiolated polypeptide compound derived from a tetanus toxin frag Thiolated polypeptide compound derived from a tetanus toxin frag

1984-04-19

1986-06-10

Phillips, Delbert R.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

530807, 530345, 530387, A61K 3700, C07K 1504

Patent

active

045943362

ABSTRACT:
The present invention relates to a new thiolated polypeptide compound derived from a fragment of tetanus toxin.
This thiolated polypeptide compound is constituted by the B-II.sub.b fragment of tetanus toxin to which at least one --SH group is directly or indirectly bound.
Application: neuropharmacological retrograde axonal transport agent for transporting a medicine to the central nervous system.

REFERENCES:
patent: 3111512 (1963-11-01), Benesch et al.
patent: 4029765 (1977-06-01), Helting
patent: 4201770 (1980-05-01), Stevens
T. B. Helting et al., J. of Biol. Chem. 252, 187-193 (1977).

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