Synergistic antibacterial compositions and method of treatment o

Drug – bio-affecting and body treating compositions – Plural fermentates of different origin

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A61K 3500

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active

045942471

ABSTRACT:
Antibiotic compositions comprising a 1-oxa .beta.-lactam antibiotic compound of the formula ##STR1## or pharmaceutically acceptable salts thereof and either tobramycin, amikacin or piperacillin exhibit synergistic activity against multiple-antibiotic-resistant organisms. The 1-oxa compound can be used in conjunction with tobramycin, amikacin or piperacillin in a method of treating infections caused by resistant organisms.

REFERENCES:
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patent: 4138486 (1979-02-01), Narisada et al.
Chanbusarakum, P. et al., "Analysis of the Interactions Between Piperacillin Ticarcillin, or Carbenicillin and Aminoglycoside Antibiotics", Antimicrobial Agents and Chemotherapy, vol. 14, No. 3, Sep. 1979, pp. 505-506.
Drusano, G. L. et al., "Moxalactam and Piperacillin: A Study of In vitro Characteristics and Pharmacokinetics in Cancer Patients", Infection 13 (1985) No. 1.

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