Process for preparing 3-phenoxy-1-azetidines and carboxamide der

Details Process for preparing 3-phenoxy-1-azetidines and carboxamide der Process for preparing 3-phenoxy-1-azetidines and carboxamide der

1983-07-06

1986-06-10

Daus, Donald G.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

C07D70504

Patent

active

045941890

ABSTRACT:
An improved process is disclosed for preparing 3-phenoxyazetidines which utilizes a phase transfer catalyst to add the phenoxy group to azetidine blocked in the 1-position by a diphenylmethane group and utilizes a stabilizing tertiary amine base to prevent dimerization during hydrogenolysis to remove the blocking group. The crude product containing diphenylmethane may be used without purification to prepare 3-phenoxy-1-azetidinecarboxamides.

REFERENCES:
patent: 3094518 (1963-06-01), Testa et al.
patent: 4031221 (1977-06-01), Helsley et al.
patent: 4226861 (1980-10-01), Cale, Jr.
patent: 4379151 (1983-04-01), Cale, Jr.
Anderson, Jr., et al., J. Org. Chem., vol. 37, No. 24, (1972) pp. 3953-3955.
Dehmlow, et al., Phase Transfer Catalysis, Verlag Chemie, Weinheim, 1980, pp. 86-93.
Starks, et al., Phase Transfer Catalysis, Academic Press, N.Y., 1978, pp. 128-138.

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