Certain heterocyclic-methylthioalkyl guanidine derivatives

Details Certain heterocyclic-methylthioalkyl guanidine derivatives Certain heterocyclic-methylthioalkyl guanidine derivatives

1979-05-14

1981-08-04

Rotman, Alan L.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Parasitic organism or component thereof or substance...

424270, 424272, 548136, 548138, 548142, 548182, 548190, 548193, 548213, 548214, 548243, 548245, 548240, C07D27728, C07D27502, C07D28508, A61K 31425

Patent

active

042822343

ABSTRACT:
The compounds are N-(heterocyclomethylthioalkyl)derivatives of alkylguanidines, C-alkyl and C-aryl amidines and S-alkylisothioureas. The compounds may also have N'-lower alkyl or N'-(heterocyclomethylthioalkyl)substituents. Three compounds of the invention are S-methyl-N-[2-(5-methyl-4-imidazolylmethylthio)ethyl]isothiourea, N,N'-bis-[2-(5-methyl-4-imidazolymethylthio)ethyl]acetamidine, N,N'-bis-[2-(5-methyl-4-imidazolymethylthio)ethyl]N"-methylguanidine. The compounds of this invention are histamine H.sub.2 -antagonists.

REFERENCES:
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patent: 3950333 (1976-04-01), Durant et al.
patent: 3979398 (1976-09-01), White
patent: 4025527 (1977-05-01), Durant et al.
patent: 4034101 (1977-07-01), Durant et al.
patent: 4036971 (1977-07-01), Durant et al.
patent: 4049671 (1977-09-01), Durant et al.
patent: 4109003 (1978-08-01), Durant et al.
patent: 4120966 (1978-10-01), Brown et al.
Derwent Abstract No. 19437V of Belgian Pat. No. 804,144 (Patent Published Feb. 28, 1974-Smith Kline & French).
Derwent Abstract No. 19438V of Belgian Pat. No. 804,145 (Patent Published Feb. 28, 1974-Smith Kline & French).
Derwent Abstract No. 03751w of Belgian Pat. No. 816,850 (Patent Published Dec. 1974).

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