Process for the synthesis of penems and penams

Details Process for the synthesis of penems and penams Process for the synthesis of penems and penams

1984-08-29

1987-05-05

Rizzo, Nicholas S.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

540313, 514192, 540360, C07D49900, A61K 31425

Patent

active

046634517

ABSTRACT:
Described is a novel process for the preparation of penams and penems useful as antibacterial agents, which comprises the reaction of an appropriate 4-substituted-azetidin-2-one with a base, followed by reaction of the thereby formed penam compound with an oxidating agent and a organic or inorganic base.
Also described are novel penam compounds useful as antibacterials which are prepared by the described process.

REFERENCES:
patent: 4395418 (1983-07-01), Ohki et al.
patent: 4500457 (1985-02-01), Girttli et al.

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