Leukemia-associated virus immunogen, vaccine and assay

Chemistry: natural resins or derivatives; peptides or proteins; – Peptides of 3 to 100 amino acid residues – 25 or more amino acid residues in defined sequence

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530325, 530326, 530327, 530328, 530329, 530330, 424 88, C07K 706, C07K 708, C07K 710, A61K 3900

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046634363

ABSTRACT:
The present invention relates to a leukemia-associated virus immunogens, vaccines, and assays. The immunogens are relatively short polypeptides with peptide sequences corresponding to the antigenic determinant domains of a leukemia-associated virus envelope protein. The immunogens when introduced into a host stimulate the production of antibodies which immunoreact with the polypeptides and the leukemia-associated virus.
The immunogens may be used together with other components such as adjuvants to form immunizing compositions such as vaccines. The antibodies may be used together with other components in an assay system to detect the presence of a leukemia-associated virus antigen in a body fluid sample. The antibodies can also be used in the treatment of leukemia-associated virus infections.

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Elder et al., "Nucleotide Sequence of the Envelope Gene of Gardner-Arnstein Feline Leukemia Virus B Reveals Unique Sequence Homologies with a Murine Mink Cell Focus-Forming Virus", Journal of Virology, 46:871-880, (Jun. 1983).

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