Substituted naphthalenyloxy-1,2-diaminocyclohexyl amide compound

Details Substituted naphthalenyloxy-1,2-diaminocyclohexyl amide compound Substituted naphthalenyloxy-1,2-diaminocyclohexyl amide compound

1985-07-19

1987-05-05

Brust, Joseph Paul

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

546234, 548517, 548527, 548578, 564162, 564172, C07D20706, A61K 3140

Patent

active

046633430

ABSTRACT:
Substituted naphthalenyloxy- or naphthalenylthiooxyamides of trans-1,2-diaminocyclohexanes possess selective kappa opioid receptor site binding activity and are thus useful as analgesic or diuretic agents. Methods of preparing the compounds, pharmaceutical compositions, and a method for their use as analgesic agents are also disclosed.

REFERENCES:
patent: 4098904 (1978-07-01), Szmuszkovicz
patent: 4145435 (1979-03-01), Szmuszkovicz
patent: 4598087 (1986-07-01), Horwell

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