Novel decahydroquinolinol derivatives, and pharmaceutical compos

Details Novel decahydroquinolinol derivatives, and pharmaceutical compos Novel decahydroquinolinol derivatives, and pharmaceutical compos

1985-06-13

1987-05-05

Daus, Donald G.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

546153, A61K 3147, C07D21522

Patent

active

046633308

ABSTRACT:
The invention relates to novel decahydroquinolinol derivatives represented by the general formula: ##STR1## and pharmaceutically acceptable acid addition salts thereof, in which X represents oxygen or sulphur, R represents an alkyl radical having from 1 to 3 carbon atoms, R.sub.1 represents fluorine, chlorine, bromine or methoxy, R.sub.2 represents hydrogen or methoxy or R.sub.1 and R.sub.2, when they are taken together, represent a 2,3-methylenedioxy or 3,4-methylenedioxy radical.
The compounds of the invention are inhibitors of calcium translocation at the level of the cell membrane and are useful more particularly in the treatment of pathological syndromes of the cardiovascular system such as, for instance, angina pectoris.

REFERENCES:
patent: 3882129 (1975-05-01), Prost et al.
patent: 4173636 (1979-11-01), Prost
patent: 4332805 (1982-06-01), Prost et al.
patent: 4565828 (1986-01-01), Descamps et al.
Prost, et al., Ann. Pharmaceutiques Francaises, vol. 43, No. 2, pp. 139-146 (09/85).
Prost, et al., Eur. J. Med. Chem.-Chimica Therapeutica, vol. 16, No. 2, pp. 119-123 (3-4/81).
J.A.M.A., vol. 247, No. 14, pp. 1911-1913, 1917 (04/09/82).
Prost, et al., Chemical Abstracts, vol. 80; 3398y (1974).
Prost, et al., Chemical Abstracts, vol. 95:24767t (1981).
Prost, et al., Chemical Abstracts, vol. 95:97612y (1981).
Prost, et al., Chemical Abstracts, vol. 104:224s (1986).
Search Report Of European Patent Application No. 85 870083.

Affiliated with

Also associated with

Rating

Novel decahydroquinolinol derivatives, and pharmaceutical compos does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Novel decahydroquinolinol derivatives, and pharmaceutical compos, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Novel decahydroquinolinol derivatives, and pharmaceutical compos will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-2399489