Pyrazolo[4,3-d]pyrimidine-5,7-(4H,6H)dione or -5-thione-7-one an

Details Pyrazolo[4,3-d]pyrimidine-5,7-(4H,6H)dione or -5-thione-7-one an Pyrazolo[4,3-d]pyrimidine-5,7-(4H,6H)dione or -5-thione-7-one an

1985-04-04

1987-05-05

Warden, Robert J.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

544262, A61K 3141, C07D48704

Patent

active

046633260

ABSTRACT:
Various novel analogs of pyrazolo[4,3d]pyrimidine-5,7-(4H,6H)diones and also 5-thione-7-ones, novel methods of synthesis therefor, compositions and uses are the present invention. For example, the novel 5,7-diones and 5-thione-7-ones are useful for stimulating the central nervous system reversing bronchoconstriction, and as cardiac stimulants cardiotonic agents.

REFERENCES:
patent: 4031218 (1977-06-01), El-Antably
patent: 4544556 (1985-10-01), Fedi
Robins, J. Amer. Chem. Soc., 78, p. 2418 (1956).
R. K. Robins, et al., J.O.C. 21(8), 833 (1956).
R. K. Robins, et al., JACS, 78, 2418 (1956).
R. F. Rose, J. Chem. Soc., 3448 (1952).
V. Papesh et al, J.O.C. 30(1) 199 (1965).
Ind. J. Chem. Sec. B, 21B (6) 585-6 (1982).

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