Prosthesis (i.e. – artificial body members) – parts thereof – or ai – Arterial prosthesis – Stent structure
Patent
1996-10-09
1998-10-20
Prebilic, Paul B.
Prosthesis (i.e., artificial body members), parts thereof, or ai
Arterial prosthesis
Stent structure
623 12, 427 225, 427 23, 606191, A61F 206
Patent
active
058240489
ABSTRACT:
A method for delivering a therapeutic substance to a body lumen utilizing an intravascular stent having a coating comprising a polymer and a therapeutic substance in a solid/solid solution with the polymer. The coating comprises a first coating layer nearer the stent body having a first concentration of therapeutic substance overlaid by a second porous coating layer having a second lesser concentration of therapeutic substance. The inclusion of a porous polymer coating layer on the stent helps retain the therapeutic substance on the stent during expansion of the stent and also controls the administration of the therapeutic substance following implantation. By this method, drugs such as dexamethasone can be applied to a stent, retained on a stent during expansion of the stent and elute at a controlled rate.
REFERENCES:
patent: 4292965 (1981-10-01), Nash et al.
patent: 4529614 (1985-07-01), Burns
patent: 4532929 (1985-08-01), Matei et al.
patent: 4733665 (1988-03-01), Palmaz
patent: 4753652 (1988-06-01), Langer et al.
patent: 4776337 (1988-10-01), Palmaz
patent: 4800882 (1989-01-01), Gianturco
patent: 4869909 (1989-09-01), Takahashi et al.
patent: 4886062 (1989-12-01), Wiktor
patent: 4888009 (1989-12-01), Lederman et al.
patent: 4894231 (1990-01-01), Moreau et al.
patent: 5019090 (1991-05-01), Pinchuk
patent: 5092841 (1992-03-01), Spears
patent: 5102402 (1992-04-01), Dror et al.
patent: 5102417 (1992-04-01), Palmaz
patent: 5176907 (1993-01-01), Leong
patent: 5192308 (1993-03-01), Ostapchenko
patent: 5213580 (1993-05-01), Slepian et al.
patent: 5221698 (1993-06-01), Amidon et al.
patent: 5234456 (1993-08-01), Silvestrini
patent: 5242391 (1993-09-01), Place et al.
patent: 5290266 (1994-03-01), Rohling et al.
patent: 5295978 (1994-03-01), Fan et al.
patent: 5304121 (1994-04-01), Sahatjian
patent: 5356433 (1994-10-01), Rowland et al.
patent: 5380299 (1995-01-01), Feamot et al.
patent: 5443496 (1995-08-01), Schwartz et al.
patent: 5447724 (1995-09-01), Helmus et al.
patent: 5464650 (1995-11-01), Berg et al.
patent: 5549924 (1996-08-01), Shlenker et al.
patent: 5578075 (1996-11-01), Dayton
patent: 5599352 (1997-02-01), Dinh et al.
patent: 5605696 (1997-02-01), Fury et al.
patent: 5609629 (1997-03-01), Fearnot et al.
patent: 5649977 (1997-07-01), Campbell
patent: 5679400 (1997-10-01), Tuch
patent: 5707385 (1998-01-01), Williams
"Seeding of Intravascular Stents with Genetically Engineered Endothelial Cells" by Dicket et al, in Circulation, vol. 80, No. 5 Nov. 1989.
"Restenosis and the Proportional Neointimal Response to Coronary Artery Injury: Results in a Porcine Model" by Schwartz et al., in JACC, vol. 19, No. 2, Feb. 1992 pp. 267-274.
"Restenosis After Balloon Angioplasty" by Schwartz, et al., in Circulation, vol. 82, No. 6, Dec. 1990.
Latham Daniel W.
Medtronic Inc.
Patton Harold R.
Prebilic Paul B.
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