Novel ailanthone derivative

Details Novel ailanthone derivative Novel ailanthone derivative

1985-11-04

1988-09-27

Fan, Jane T.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C07D49308

Patent

active

047743425

ABSTRACT:
An ailanthone derivative having the general formula: ##STR1## wherein R is a p-alkyl benzoic acid residue having 8 to 21 carbon atoms, a 2-methyl saturated fatty acid residue having 6 to 19 carbon atoms, a 2-methyl-2-unsaturated fatty acid residue having 4 to 19 carbon atoms, a 3,4-dimethyl-4-acyloxy-2-pentenoic acid residue having 9 to 19 carbon atoms, a 3,4,4-trimethyl-2-unsaturated fatty acid residue having 8 to 21 carbon atoms, a group having the formula ##STR2## wherein n is an integer of 1 to 13, a group having the general formula ##STR3## wherein n is an integer of 1 to 13, a trans-cinnamic acid residue, a linear saturated fatty acid residue having 3 to 22 carbon atoms, a 3-methyl-2-unsaturated fatty acid residue having 6 to 19 carbon atoms, a 3,4-dimethyl-2-unsaturated fatty acid residue having 7 to 20 carbon atoms, a terpenic acid residue, a 2-amino saturated fatty acid residue having 2 to 18 carbon atoms or a salt thereof, a 2-hydroxy saturated fatty acid residue having 3 to 18 carbon atoms, or a 3,5,5-trimethylhexanoic acid residue.

REFERENCES:
patent: 3969369 (1976-07-01), Kupchan et al.
Johnson et al., Cancer Treatment Reviews, 1975, 2, 1-31.
Pratt et al., The Anticancer Drugs, Oxford Univ. Press, N.Y., 1979, pp. 273-277.
Cassady et al., Anticancer Agents Based on Natural Product Models, 1980, pp. 255-269.
Kupchan et al., J. Org. Chem., vol. 40, No. 5, 1975, p. 645 and p. 654.

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