Process for preparing N-substituted piperazines from ethylene gl

Details Process for preparing N-substituted piperazines from ethylene gl Process for preparing N-substituted piperazines from ethylene gl

1986-10-02

1988-09-27

Daus, Donald G.

Organic compounds -- part of the class 532-570 series

Organic compounds

Nitrogen attached directly or indirectly to the purine ring...

544358, 544392, 544395, C07D29502

Patent

active

047743360

ABSTRACT:
N,N'-dialkylpiperazines are prepared by contacting ethylene glycol and a primary amine in the presence of a homogeneous ruthenium-phosphine catalyst. For example, ethylene glycol and aniline are reacted in the presence of ruthenium trichloride and triphenylphosphine to produce N,N'-diphenylpiperazine.

REFERENCES:
patent: 3029240 (1962-04-01), Erner
patent: 3037025 (1962-05-01), Godfrey
patent: 3067199 (1962-12-01), Langdon
patent: 3120524 (1964-02-01), Godfrey
patent: 3647795 (1972-03-01), Bluestein et al.
patent: 3697524 (1972-10-01), Tomalia et al.
patent: 3907802 (1975-09-01), Demmering
patent: 4123462 (1978-10-01), Best
patent: 4709034 (1987-11-01), Marsella
Tsuji et al., Tetrahedron Letters, vol. 27, No. 3, pp. 377-380 (1986).
Watanabe et al., J. Org. Chem., 1984, 49, 3359-3363.
Tsuji et al., J. Org. Chem., 1985, 50, 1365-1370.

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