Process of preparing bis (trifluoromethylphenyl) methanol

Details Process of preparing bis (trifluoromethylphenyl) methanol Process of preparing bis (trifluoromethylphenyl) methanol

1990-03-12

1991-05-21

Lone, Werren B.

Organic compounds -- part of the class 532-570 series

Organic compounds

Oxygen containing

568715, C07C 39367

Patent

active

050177303

ABSTRACT:
The invention provides a process for easily, efficiently and economically preparing bis(trifluoromethylphenyl)methanol from either toluoyl chloride or a trihalomethylbenzoyl chloride. First the starting compound is reacted with toluene in the presence of a strong acid catalyst such as a perfluoroalkylsulfonic acid to form a benzophenone derivative, CX.sub.3 C.sub.6 H.sub.4 --CO--C.sub.6 H.sub.4 CH.sub.3, wherein X is H, F, Cl or Br. Next, by chlorination the benzophenone derivative is converted into CY.sub.3 C.sub.6 H.sub.4 --CO--C.sub.6 H.sub.4 CCL.sub.3, wherein Y is F or Cl, and then the chlorinated intermediate is fluorinated into bis(trifluoromethyl)benzophenone. By reduction of carbonyl group of this benzophenone derivative the aimed compound is obtained.

REFERENCES:
J. Org. Chem., vol. 49, pp. 409-413, (1984), by David Kelly et al.

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