N-indolylethyl-sulphonic acid amides and their use

Details N-indolylethyl-sulphonic acid amides and their use N-indolylethyl-sulphonic acid amides and their use

1986-04-14

1988-09-27

Raymond, Richard L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

514253, 514254, 514269, 514274, 514309, 514312, 514323, 514339, 514362, 514363, 514367, 514369, 514372, 514381, 514384, 514394, 514397, 514418, 5142352, 544 585, 544143, 544316, 544319, 544373, 544405, 546141, 546153, 546157, 546201, 546273, 548126, 548136, 548159, 548186, 548209, 548213, 548251, 548255, 548265, 548327, 548336, 548507, A61K 3140, C07D20914

Patent

active

047742402

ABSTRACT:
The invention relates to N-indolylethyl-sulphonic acid amides of the formula ##STR1## wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4 and R.sup.5 are defined in the specification and X is carboxyl, alkoxycarbonyl, cyano or carboxamido. These active compounds are useful in medicaments in combating thromboses, thromboembolisms, allergies or asthmatic disorders.

REFERENCES:
Journal of Pharmaceutical Sciences, Band 60, Nr. 4, Apr. 1971, Seiten 636-637; B. T. Ho et al.: "Hydroxyindole-O-methyltransferas e VI: Inhibitory Activities of Substituted benzoyltryptamines and benzenesulfonyltryptamines".
Journal of Medicinal Chemistry, Band 14, Nr. 6, Jun. 1971, Seiten 553-554; B. T. Ho et al.; "Central Nervous System Depressive Activity of Some Admides of Tryptamine" *Tabelle II, Berbindungen 10-13*.
Chemical Abstracts, Band 94, Nr. 19,11. May 1981, Seite 637, nr. 156681z, Columbus, Ohio, U.S.; D. R. Lagidze et al.: "Synthesis of Some New Analogs of Melatonin and Beta-Carboline from 4-Phenylpentanoic Acid", IZV. AKAD. NAUK GRUZ. SSR, SER. KHIM. *Zusammenfassung*.
Chemical Abstracts, Band 87, Nr. 19, 7. Nov. 1977, Seite 255, Nr, 148178f, Columbus, Ohio, U.S.; M. Wiechmann: "Scope and Limitations of the Analytical Use of Dansyl Chloride. I. The Reaction of Aromatic Sulfonyl Chlorides with Aliphatic Tertiary Amines: The Microanalytical Aspects of the Himsberg Test", Hoppe-SeylercS Z. Physiol. Chem. 1977, 358(8), 967-80 *Zusammenfassung*.
Journal of the Chemical Society, Perkin Transactions I, 1973, Seiten 1602-1606; A. S. Bailey et al.: "Further Examination of the Reactions of Simply Indoles with Arenesulphonyl Azides" *Seite 1605, Spalte 1, Absatz 2*.

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