Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Patent
1994-03-16
1997-04-08
Schain, Howard E.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
514 16, 514 17, 514 18, 530321, 530324, 530328, A61K 3736, A61K 3800, C07K 1300
Patent
active
056187904
ABSTRACT:
Lipophilic and amphiphilic therapeutic or diagnostic agents having water solubilizing groups attached thereto by bonds that can be cleaved readily by one or more of the various proteases that are active in the extracellular fluid or on the surfaces of cells in many types of malignant tissue may accumulate selectively in such malignant tissues. Protease mediated removal of the water solubilizing groups converts such drugs into lipophilic or amphiphilic forms which are more soluble in plasma membrane lipids and which therefore enter cells more readily. Since the extracellular fluid in most non-malignant tissues under normal circumstances has little such protease activity, removal of the water solubilizing groups takes place primarily within malignant tissues, with consequent preferential accumulation of the lipophilic or amphiphilic forms of the drug within malignant tissues. Certain lipophilic and amphiphilic porphyrins and chlorins may be modified by the addition of water solubilizing groups, such as alcohols, which are attached by short polypeptide chains, that are stable while in the circulation but are cleaved by proteases in malignant tissue to provide novel compounds useful for the photodynamic therapy of cancer.
REFERENCES:
Isonnguth et al., Biochimica et Biophysica Acta 924 pp. 19-26 (1987).
Keller et al. Macromolecules, 23, pp. 428-311 (1990).
Sezaki et al. Crit. Rev. Ther. Drugs Carrier Syst.. 1(1), pp. 1-38 (1984).
Kennedy James C.
Pottier Roy H.
Ringuet Michel
Hicks Richard J.
Queen's University at Kingston
Schain Howard E.
Touzeau Lynn
LandOfFree
Protease mediated drug delivery system does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Protease mediated drug delivery system, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Protease mediated drug delivery system will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-2397774