Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...
Patent
1986-06-24
1989-04-18
Springer, David B.
Organic compounds -- part of the class 532-570 series
Organic compounds
Heterocyclic carbon compounds containing a hetero ring...
548496, 548497, 548532, 562445, 562562, 562563, 562570, 562554, C07D20920, C07D23318, C07C 9900
Patent
active
048228907
ABSTRACT:
A method for the production of substantially 100% pure N.alpha.-urethane protected amino acids is disclosed. This method eliminates the formation of di-peptide and tri-peptide contaminants. Reaction of blocking reagents at the carboxylate site on a protected peptide is prevented by the application of labile amino acid esters. Subsequent removal of the ester yields, in ultra-high purity, the N.alpha.-protected amino acid. The substantially 100% pure N.alpha.-urethane protected amino acid are also disclosed.
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Gould George M.
Hoffmann-La Roche Inc.
Prlina Julie M.
Saxe Jon S.
Springer David B.
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