Preparation of difluoropyridine compounds

Details Preparation of difluoropyridine compounds Preparation of difluoropyridine compounds

1988-02-29

1989-04-18

Rotman, Alan L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C07D21326

Patent

active

048228877

ABSTRACT:
Alpha, beta-difluoropyridine compounds are prepared by contacting a 2,3-dihalopyridine compound or suitable precursor thereof with an effective amount of KF or CsF in a polar aprotic solvent (diluent) at an elevated temperature under substantially anhydrous conditions with removal of the difluoropyridine products essentially as they are formed. The starting material may optionally be added as the reaction proceeds to minimize decomposition. The reaction is also optionally conducted in the presence of an acid scavenger and/or a crown ether or other phase-transfer catalyst.

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Finger et al., J. Organic Chem., 28, 1666-1668 (1963).
Chambers et al., Proc. Chem. Soc., 1964, p. 83.
Chambers et al., J. Chem. Soc., 1964, 3573-3576.
Newkome and Paudler, Contemporary Heterocyclic Chemistry, pp. 262-264.
Banks et al., J. Chem. Soc., 1865, 594-597.
Abramovitch, Pyridine and its Derivatives Part 2 Supplement, pp. 422-423.

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