Methods for detecting PDGF agonist or antagonist activity using

Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...

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536 235, 435 691, 435 15, C12Q 100

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056186789

ABSTRACT:
Isolated DNA molecules that encode a novel PDGF receptor are disclosed. The receptor binds the AA, AB and BB isoforms of PDGF with high affinity. Cells transfected or transformed with the DNA molecules are also disclosed. The cells can be used within methods for detecting PDGF agonist or antagonist activity in a test compound.

REFERENCES:
Claesson-Welsh et al., "Identification and Structural Analysis of the A Type Receptor for Platelet-derived Growth Factor," J. Biol. Chem. 264(3):1742-1747, 1989.
Claesson-Welsh et al., "cDNA cloning and expression of the human A-type platelet-derived growth factor (PDGF) receptor establishes strutural similarity to the B-type PDGF receptor," Proc. Natl. Acad. Sci. USA 86:4917-4921, 1989.
Hart et al, "Biochemical Evidence for Multiple Classes of Platelet-Derived Growth Factor Receptor," Growth Factors and Their Receptors: Genetic Control and Rational Application, Alan R. Liss, Inc., 1989, pp. 297-305.
Gronwald et al., "Cloning and expression of a cDNA coding for the human platelet-derived growth factor receptor: Evidence for more than one receptor class," Proc. Natl. Acad. Sci. USA 85:3435-3439, 1988.
Hart et al., "Two Classes of PDGF Receptor Recognize Different Isoforms of PDGF," Science 240:1529-1531, 1988.
Hart et al., "Synthesis, Phosphorylation, and Degradation of Multiple Forms of the Platelet-derived Growth Factor Receptor Studied Using a Monoclonal Antibody," J. Biol Chem. 262(22):10780-10785, 1987.
Yarden et al., "Structure of the receptor for platelet-derived growth factor helps define a family of closely related growth factor receptors," Nature 323:226-232, 1986.
Daniel et al., "Purification of the platelet-derived growth factor receptor by using an anti-phosphotyrosine antibody," Proc. Natl. Acad. Sci. USA 82:2684-2687, 1985.
Claesson-Welsh et al., "cDNA Cloning and Expression of a Human Platelet-Derived Growth Factor (PDGF) Receptor Specific for B-Chain-Containing PDGF Molecules," Mol. Cell. Biol. 8(8):3476-3486, 1988.
Maniatis et al., "Transformation of Escherichia coli by Plasmid DNA," Molecular Cloning: A Laboratory Manual, Cold Spring Harbor Laboratory:249-251, 1982.
Heldin et al., "Binding of Different Dimeric Forms of PDGF to Human Fibroblasts: Evidence For Two Separate Receptor Types", EMBO J. 7:1387-1393, 1988.
Escobedo et al., "A Common PDGF Receptor Is Activated by Homodimeric A and B Forms of PDGF," Science 240:1532-1534, 1988.
Beggs, "Transformation of yeast by a replicating hybrid plasmid," Nature 275:104-108, 1978.
Bowen-Pope et al., Journal of Biological Chemistry, vol. 257, pp. 5161-5171, 1982.
Matsui et al. Science, vol. 243, pp. 800-804, 1989.

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