Methods for the diagnosis of peripheral nerve damage

Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Blood proteins or globulins – e.g. – proteoglycans – platelet...

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530359, 5303871, 5303881, 5303891, 435 71, C07K 1600, C07K 100, C07K 1400, C12P 2108

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058440976

ABSTRACT:
Methods of diagnosing peripheral nerve damage, including diagnosing and monitoring chronic back and cervical pain are disclosed. The methods involve subjecting a body fluid sample from a patient suspected of having chronic lumbar or cervical pain and peripheral nerve damage to two-dimensional electrophoresis or an immunoassay and measuring relative amounts of protein or proteins which increase or decrease in concentration as compared to a standard control. A preferred method employs an Apo-E variant as a marker of peripheral nerve damage. Also disclosed are kits for use with the diagnostic methods.

REFERENCES:
patent: 3540850 (1970-11-01), Halpaap
patent: 3873433 (1975-03-01), Seidel et al.
patent: 3930983 (1976-01-01), Sieber
patent: 3979507 (1976-09-01), Baker
patent: 4118469 (1978-10-01), Caldwell et al.
patent: 4124470 (1978-11-01), Dahms
patent: 4178285 (1979-12-01), Felts et al.
patent: 4211530 (1980-07-01), Goverde et al.
patent: 4264589 (1981-04-01), Felts et al.
patent: 4311788 (1982-01-01), Heuck et al.
patent: 4416998 (1983-11-01), Adams et al.
patent: 4466951 (1984-08-01), Pittman et al.
patent: 4468466 (1984-08-01), Morrissey
patent: 4558007 (1985-12-01), Anderson et al.
patent: 4579735 (1986-04-01), Heimburger et al.
patent: 4579825 (1986-04-01), Siedel et al.
patent: 4603106 (1986-07-01), Cerami et al.
patent: 4619895 (1986-10-01), Cubicciotti et al.
patent: 4645748 (1987-02-01), Hurwitz et al.
patent: 4648974 (1987-03-01), Rosskopf et al.
patent: 4654301 (1987-03-01), Anderson et al.
patent: 4666578 (1987-05-01), Yamamoto
patent: 4677057 (1987-06-01), Curtiss et al.
patent: 4698298 (1987-10-01), Dedieu et al.
patent: 4708939 (1987-11-01), Siedel et al.
patent: 4722893 (1988-02-01), Shigeta et al.
patent: 4746605 (1988-05-01), Kerscher et al.
patent: 4772549 (1988-09-01), Fiossare
patent: 4778768 (1988-10-01), Heinegard et al.
patent: 4791066 (1988-12-01), Ishiguro
patent: 4820505 (1989-04-01), Ginsberg et al.
patent: 4822776 (1989-04-01), Cerami et al.
patent: 4828986 (1989-05-01), Smith et al.
patent: 4877746 (1989-10-01), Jansson et al.
patent: 4892814 (1990-01-01), Harrington et al.
patent: 4892815 (1990-01-01), Kerscher et al.
patent: 4895558 (1990-01-01), Cham
patent: 4920115 (1990-04-01), Nestler et al.
patent: 4923439 (1990-05-01), Seidel et al.
patent: 4935363 (1990-06-01), Brown et al.
patent: 4943522 (1990-07-01), Eisinger et al.
patent: 4943527 (1990-07-01), Protter et al.
patent: 4945040 (1990-07-01), Fless et al.
patent: 4948723 (1990-08-01), Hermon-Taylor et al.
patent: 4962091 (1990-10-01), Eppstein et al.
patent: 4970144 (1990-11-01), Fareed et al.
patent: 4973638 (1990-11-01), Sparrow et al.
patent: 4975528 (1990-12-01), Kaminski et al.
patent: 4978503 (1990-12-01), Shanks et al.
patent: 4997916 (1991-03-01), Aviv et al.
patent: 5030722 (1991-07-01), Snyder et al.
patent: 5032511 (1991-07-01), Takahashi et al.
patent: 5045480 (1991-09-01), Johnson et al.
patent: 5049488 (1991-09-01), Baer et al.
patent: 5055396 (1991-10-01), Curtiss et al.
patent: 5059528 (1991-10-01), Bollen et al.
patent: 5064769 (1991-11-01), Gambert et al.
patent: 5089602 (1992-02-01), Iskiker et al.
Atlantic Antibodies, "Apolipoprotein E test kit", in The Medical Observer, vol. 21, p. 16, 1989.
VanderPutten et al, "Increased apolipoprotein-E concentrations in individuals suffering chronic low back syndrome identified by two-dimensional gel electrophoresis", Applied and Theoretical Electrophoresis, vol. 3, pp. 247-252, Oct. 13, 1993.
Carlsson et al, "Clinical relevance of the quantification of apolipoprotein E in cerebrospinal fluid" Clinica Chimica Acta, vol. 196, pp. 167-176, 1991.
Basu et al., Proc. Natl. Acad. Sci. USA, vol. 78, No. 12, pp. 7545-7549 Dec. 1981.
Basu et al., Science, vol. 219, Feb., 1983, pp. 871-873.
Boyles et al., J. Clin. Invest, vol. 76, Oct. 1985, 1501-1513.
Boyles et al., J. Clin. Invest, vol. 83, Mar. 1989, 1015-1031.
Boyles et al., J. Biol. Chem., vol. 265, No. 29, Oct., 1990, pp. 17805-17815.
Breslow, Ann. Rev. Biochem. 1985, 54:699-727.
Cuthbert et al., Proc. Natl. Acad. Sci. USA, vol. 81, pp. 4539-4543, Jul., 1984.
Elshourbagy et al., Proc. Natl. Acad. Sci. USA, vol. 82, pp. 203-207, Jan., 1985.
Folkman et al., Nature, vol. 273, Jun. 1, 1978 pp. 345-349.
Frohlich et al., Clin. Biohem., vol. 22, pp. 51-56, 1989.
Hallman et al., Am. J. Hum. Genet. 49:338-349, 1991.
Kostner, Biochemical Society Transactions, 629th Meeting, London, vol. 17, pp. 639-641.
Lalazar et al., J. Biol. Chem., vol. 264,No. 15, May 25, 1989, pp. 8447-8450.
Mahley, Science, vol. 240, Apr. 1988, pp. 622-630.
Majack et al., J. Cell. Biol., vol. 107, Sep. 1988, 1207-1213.
Menzel et al., Electrophoresis 1986, 7, 492-495.
Muller et al., Journal of Neuroscience Research 18:222:229 (1987).
Pitas, J. Biol. Chem, vol. 262, No. 29, Oct. 15, 1987, pp. 14352-14360.
Pitas et al., Biochimica et Biophysica Acta 917 (1987) 148-161.
Rall, Jr. et al., J. Clin. Invest., vol. 83, Apr. 1989, pp. 1095-1101.
Roheim et al., Proc. Natl. Acad. Sci. USA, vol. 76, No. 9, pp. 4646-4649 Sep., 1979.
Roheim et al., European Heart Journal (1990) 11 (Supplement E), 225-229.
Ross, The New England Journal of Medicine, vol., 314, No. 8, Feb. 20, 1986, pp. 488-500.
Snipes et al., Proc Natl. Acad. Sci. USA, vol. 83, pp. 1130-1134, Feb., 1986, Neurobiology.
Sprecher et al., Clin. Chem. 30/12, 2084-2092 (1984).
Utermann et al., J. Lipid Research, vol. 25, 1984, pp. 378-382.
Weisgraber et al., J. Biol. Chem., vol. 257, No. 5, Mar. 10, 1982, pp. 2518-2521.
Weisgraber et al., Biochemical and Biophysical Research Communications, vol., 157, No. 3, 1988, pp. 1212-1217.
Werb et al., J. Exp. Med., vol. 158, Oct., 1983, pp. 1272-1293.
Wilson et al., Science, vol. 252, Jun. 28, 1991, pp. 1817-1822.
Zannis et al., Biochemistry, vol. 20, No. 4, 1981, pp. 1033-1041.
Zannis et al., J. Lipid Research, vol. 23, 1982, pp. 911-914.
Ahonen et al., Acta Neurologica Scandinavica, vol. 58, Fasc. 6 (1978) 358-365.
Felgenhauer et al., Clinica Chimica Acta, 100 (1980) pp. 121-132.
Frot et al., Marker Proteins in Inflammation, pp. 253-273 (1982).
Harrington et al., Clin. Chem. vol. 30, No. 12, pp. 1933-1937 (1982).
Kushner, Annals of the New York Acad. of Sci., pp. 39-48 (1982).
McCarty, Annals of the New York Acad. of Sci., pp. 1-10 (1982).
Merril et al., Clin. Chem. vol. 28, No. 4, pp. 1015-1020 (1982).
Tracy et al., Clin. Chem. vol. 28, No. 4, pp. 890-899 (1982).
Tracy et al., Clin. Chem. vol. 28, No. 4, pp. 900-907 (1982).
Tracy et al., Clin. Chem. vol. 28, No. 4, pp. 915-919 (1982).
Tracy et al., J. Clin. Laboratory Automation, vol. 3, No. 4, (1983) pp. 235-243.
Varma et al., Experimental Cell Research 173 (1987) pp. 163-173.
Willard et al., Clin. Chem. vol. 28, No. 4, pp. 1067-1073 (1982).
Havel et al., "Lipoproteins and Lipid Transport" in Metabolic Control and Diseases, pp. 393-494 (1980).
Hui et al., J. Biol. Chem., pp. 11775-11781 (1980).
Hochstrasser et al., Applied & Theoretical Electro., pp. 73-76 (1988).
Ignatius et al., Science, vol. 236, pp. 959-962 (1987).
Ignatius et al., PNAS USA, vol. 83, pp. 1125-1129 (1986).
Ignatius et al., Prog. in Brain Res., vol. 71, pp. 177-184 (1987).
Carlsson, et al., Clinica Chimica Acta, "Clinical relevance of the gantification of apoliprotein E in cerebrospinal fluid", vol. 196, (1991) pp. 167-176.
Harrel, et al., Biochem. BIophys. Aeta, 573:175-183, 1979.
Horie, et al., The Functional Characteristics of Human Apolipoprotein F. Variant (Cysteine at Residue 142), May Explain Its Association with Dominant Expression of Type III Hyperlipoprotemia, JBC 267 (3) 1962-1968 (1992).
Lettimaki, et al., Association of Apolipoprotein E and B Polymorphism w/Serum Lipids, Ann. Med., 23:657-662 1991.
Xhignesse, et al., Influence as of Common Variants of Apol-protein E on on Measures of Lipid Metabolis in a Sample Selected for Health, Arteriosclter. Thromb. 11(4):1100-1110 (1991).

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