Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues
Patent
1994-12-14
1998-12-01
Walsh, Stephen
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
435 71, 435 651, 4352523, 4353201, 530300, 536 231, 536 235, C07K 1400
Patent
active
058440798
ABSTRACT:
The present invention concerns the discovery that proteins encoded by a family of vertebrate genes, termed here hedgehog-related genes, comprise morphogenic signals produced by embryonic patterning centers, and are involved in the formation of ordered spatial arrangements of differentiated tissues in vertebrates. The present invention makes available compositions and methods that can be utilized, for example to generate and/or maintain an array of different vertebrate tissue both in vitro and in vivo.
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Ingham Philip W.
McMahon Andrew P.
Tabin Clifford J.
Arnold Beth E.
President and Fellows of Harvard College
Sorensen Kenneth H.
Vincent Matthew P.
Walsh Stephen
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