Excitatory amino acid receptor antagonists

Details Excitatory amino acid receptor antagonists Excitatory amino acid receptor antagonists

1996-04-02

1998-12-01

Gerstl, Robert

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heavy metal containing doai

514277, 514345, 514351, 514359, 514381, 514384, 514461, 514473, 514562, 544316, 548253, 5482644, 5482672, 549 55, 549438, 549461, 549466, 560 38, 560 39, 562441, 562443, 562444, A61K 31435, C07C22936

Patent

active

058439978

ABSTRACT:
The present invention provides novel compounds that affect excitatory amino acid receptors and are useful in the treatment of neurological disorders. This invention also provides synthetic methods for the preparation of the novel compounds.

REFERENCES:
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Chang, et al., "Study of the stereoselectivity of L-glutamate receptors by synthetic 4 (R)-and 4(S)-substituted L-glutamate analogues", Brain Research, 604, 86-69 (1993).
Hon, Chan, and Gong, "Synthesis of (2S, 4S) and (2S, 4R) -4-Substituted Glutamic Acid Analogues For Neuroexcitatory Activity Studies", Heterocycles, 31, 191-195 (1990).
Baldwin, et al., "Stereospecific Amino Acid Synthesis; Preparation of the .gamma.-Anion derived from Glutamic Acid", J. Chem. Soc., Commun, 828-829 (1988).
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