Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1997-10-31
1998-12-01
Rose, Shep K.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
A61K 3135
Patent
active
058439870
ABSTRACT:
The present invention relates to the use of ellagic acid for the treatment of gastrointestinal disorders by stimulating the motility of the GI tract. In particular the present invention relates to a method of treatment of constipation, heartburn, non ulcer dyspepsia, GERD, and/or esophagitis, with a pharmaceutical composition comprising a safe and effective amount of ellagic acid or pharmaceutically acceptable salts or esters thereof. Preferably the ellagic acid is administered perorally.
REFERENCES:
patent: 5066671 (1991-11-01), Caufield
patent: 5104894 (1992-04-01), Josephy et al.
patent: 5137896 (1992-08-01), Van Daele
patent: 5171864 (1992-12-01), Lee
patent: 5229516 (1993-07-01), Musser et al.
Bhargava et al., "Preliminary Pharmacology of Ellagic Acid from Juglans nigra (Black Walnut)", J. of Pharmaceutical Sciences, vol. 57, No. 10, pp. 1728-1732 (1968).
Press et al., "Some Physico-Chemical Properties of Ellagic Acid", J. Appl. Chem., vol. 19, pp. 247-251 (1969).
Osawa et al., "Inhibition of Lipid Peroxidation by Ellagic Acid", J. Agric. Food Chem., vol. 35, No. 5, pp. 808-812 (1987).
Twaij et al., Pharmacological, Phytochemical and Antimicrobial Studies on Myrtus communis., J. Biol., Sci., Res., vol. 19, No. 1, pp. 29-39 (1988).
Retz, "Identification of Purgative Principle of Terminalia", The Indian J. of Pharmacy, vol. 30, No. 10, pp. 233-234 (1968).
Teel et al., "Disposition of the Plant Phenol Ellagic Acid in the Mouse Following Oral Administration by Gavage", Xenobiotica, vol. 18, No. 4, pp. 397-405 (1988).
Dhingra et al., "Determination of Free Ellagic Acid by Reversed-phase High-performance Liquid Chromatography", J. of Chromatography, vol. 447, pp. 284-286 (1988).
Daniel et al., "Extraction, Stability, and Quantitation of Ellagic Acid in Various Fruits and Nuts", J. of Food Composition and Analysis, vol. 2, pp. 338-349 (1989).
Saijo et al., "Tannins and Related compounds LXXXIV. Isolation and Characterization of Five New Hydrolyzable Tannins from the Bark of Mallotus japonicus", Chem. Pharm. Bull., vol. 37, No. 8, pp. 2063-2070 (1989).
Lin et al., "Identification and Reduction of Ellagic Acid in Muscadine Grape Juice", J. of Food Science, vol. 55, No. 6, pp. 1607-1609 (1990).
Wilson et al., "Quantitative Determination of Ellagic Acid", J. Agric. Food Chem., vol. 38, pp. 1678-1683 (1990).
Murakami et al., "Inhibition of Gastric H+, K+-ATPase and Acid Secretion by Ellagic Acid", Planta Med., vol. 57, pp. 305-308 (1991).
Daniel et al., "The Effects of pH and Rat Intestinal contents on the Liberation of Ellagic Acid From Purified and Crude Ellagitannins", J. of Natural Products, vol. 54, No. 4, pp. 946-952 (1991).
Sawamura et al., "Inhibitory Effects of Ellagic Acid on glucosyltransferases from Mutans Streptococci", Biosci. Biotech. Biochem., vol. 56, No. 5, pp. 766-768 (1992).
Josephy et al., "Ellagic Acid and synthetic Analogues as Inhibitors of Mutagenesis and Carcinogenesis", Cellular Targets for Chemoprevention, 1992.
Ohemeng et al., "DNA Gyrase Inhibitory and antibacterial Activity of Some Flavones(1)", Bioorganic & Medicinal Chem. Letters, vol. 3, No. 2, pp. 225-230 (1993).
Khambe Deepa Ashok
Rajagopalan Tuticorin Govindachari
Howell John M.
Rasser Jacobus C.
Rose Shep K.
The Procter & Gamble & Company
Zea Betty J.
LandOfFree
Method of stimulating gastrointestinal motility with ellagic aci does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Method of stimulating gastrointestinal motility with ellagic aci, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method of stimulating gastrointestinal motility with ellagic aci will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-2396069