Tricyclic benzazepine vasopressin antagonists

Details Tricyclic benzazepine vasopressin antagonists Tricyclic benzazepine vasopressin antagonists

1997-07-08

1998-12-01

Shah, Mukund J.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514 80, 5142328, 514280, 514281, 514282, 514286, 514287, 544125, 544126, 546 23, 546 42, 546 43, 546 44, 546 48, 546 63, 546 65, 546108, C07D22112, C07D41300, A61K 3144, A61K 31535

Patent

active

058439528

ABSTRACT:
Tricyclic compounds of the general Formula I: ##STR1## as defined herein which exhibit antagonist activity at V.sub.1 and/or V.sub.2 receptors and exhibit in vivo vasopressin antagonist activity, methods for using such compounds in treating diseases characterized by excess renal reabsorption of water, and processes for preparing such compounds.

REFERENCES:
patent: 5512563 (1996-04-01), Albright et al.
International Union of Pure and Applied Chemistry (IUPAC), vol. 82, 1960, p. 5566.
Drug Evaluations, 6th Ed., 1986, Amer. Medical Assn., pp. 160-162.
Cecil Textbook of Medicine, 19th Ed., 1992, Wynoaarden, M.D., Editor, pp. 2075-2079.
Yamamura, et al., Science, 252, pp. 572-574, 1991.
Yamamura, et al., Br. J. Pharmacol., 105, pp. 787-791 (1992).
Albright et al.; Chemical Abstract 123:313792 for Canadian Patent 2,128,955 (Jan. 30, 1995).

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