Nucleic acids encoding human NIK protein

Details Nucleic acids encoding human NIK protein Nucleic acids encoding human NIK protein

1997-07-03

1998-12-01

McKelvey, Terry A.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Recombinant dna technique included in method of making a...

435 691, 435243, 4353201, 435325, 435410, 536 231, 536 235, 536 2431, C12P 2106, C12N 100, C12N 510, C12N 1512

Patent

active

058437215

ABSTRACT:
The invention provides methods and compositions relating to a novel kinase, NIK, involved in NF.kappa.B activation. The polypeptides may be produced recombinantly from transformed host cells from the disclosed NIK encoding nucleic acids or purified from human cells. The invention provides isolated NIK hybridization probes and primers capable of specifically hybridizing with the disclosed NIK genes, NIK-specific binding agents such as specific antibodies, and methods of making and using the subject compositions in diagnosis, therapy and in the biopharmaceutical industry.

REFERENCES:
Malinin et al, Nature, Feb. 6, 1997, vol. 385: pp. 540-544.

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