Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Recombinant dna technique included in method of making a...
Patent
1996-07-26
1998-12-01
Walsh, Stephen
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Recombinant dna technique included in method of making a...
536 235, 4353201, 435325, 530350, C12N 1509, C12N 1511, C12N 1563, C12N 510
Patent
active
058437142
ABSTRACT:
The present invention provides polynucleotides which identify and encode a novel human proteolipid (PLHu). The invention provides for genetically engineered expression vectors and host cells comprising the nucleic acid sequence encoding PLHu. The invention also provides for the use of substantially purified PLHu and its agonists in the commercial production of recombinant proteins for the treatment of diseases associated with the expression of PLHu. Additionally, the invention provides for the use of antisense molecules to PLHu in the treatment of diseases associated with the expression of PLHu. The invention also describes diagnostic assays which utilize diagnostic compositions comprising the polynucleotides which hybridize with naturally occurring sequences encoding PLHu and antibodies which specifically bind to the protein.
REFERENCES:
patent: 5508164 (1996-04-01), Kausch et al.
Stratagene (1994) pp. 154-159.
Wallace et al. (1987) Methods in Enzymology 152 : 432-442.
Fischer et al. (1994) J. Biol. Chem. 269 : 24912-24919.
Arai, H., et al., "Inhibition of the Coated Vesicle Proton Pump and Labeling of a 17,000-Dalton Polypeptide by N,N'-Dicyclohexylcarbodiimide", J. Biol, Chem., 262:11006-11011 (1987).
Eytan, G.D., et al., "Selective Incorporation of Membrane Proteins into Proteoliposomes of Different Compositions", J. Biol. Chem., 252:3208-3213 (1977).
Finbow, M.E., et al., "Ductin--a proton pump component, a gap junction channel and a neurotransmitter release channel", BioEssays 17:247-255 (1995).
Fischer, I., et al., "Expression of Plasmolipin in Oligodendrocytes", J. Neurosci. Res., 28:81-89 (1991).
Krutovskikh V., et al., "Sequential changes of gap-junctional intercellular communications during multistage rat liver carcinogensis: direct measurement of communication in vivo", Carcinogenesis, 12:1701-1706 (1991).
Nelson, H., et al., "Molecular Cloning of cDNA Encoding the C Subunit of H.sup.+ -ATPase from Bovine Chromaffin Granules", J. Biol. Chem., 265:20390-20393 (1990).
Rancano, C., et al., "Genomic Structure and Subcellular Localization of MAL, a Human T-cell-specific Proteolipid Protein", J. Biol. Chem., 269:8159-8164 (1994).
Sapirstein, V.S., et al., "Circular Dichroism and Fluorescence Studies on a Cation Channel Forming Plasma Membrane Proteolipid", Biochemistry, 22:3330-3335 (1983).
Sapirstein, V.S., et al., "Amyloid precursor protein is enriched in axolemma and periaxolemmal-myelin and associated clathrin-coated vesicles," J. Neurosci. Res., 37:348-358 (1994).
Schaeren-Wiemers, N., et al., "Characterization of a rat gene, rMAL, encoding a protein with four hydrophobic domains in central and peripheral myelin," J. Neurosci., 15:5753-5764 (1995).
Tosteson, M.T., et al., "Protein Interactions with Lipid Bilayers: The Channels of Kidney Plasma Membrane Proteolipids", J. Membr. Biol., 63:77-84 (1981).
Trosko, J.E., et al., "Symposium: Cell Communication in Normal and Uncontrolled Growth", Radiation Res., 123:241-251 (1990).
Zacchetti, D., et al., "VIP17/MAL, a Proteolipid in Apical Transport Vesicles", FEBS Letters, 377:465-469 (1995).
Marra, M. et al., (GI 1428191) EMBL Database (Accession W98280), National Center for Biotechnology Information, National Library of Medicine, Bethesda, Maryland, 20894.
Marra, M. et al., (GI 1283219) EMBL Database (Accession W12117), National Center for Biotechnology Information, National Library of Medicine, Bethesda, Maryland, 20894.
Au-Young Janice
Bandman Olga
Goli Surya K.
Hillman Jennifer L.
Billings Lucy J.
Incyte Pharmaceuticals Inc.
Pak Michael D.
Walsh Stephen
LandOfFree
DNA encoding a novel human proteolipid does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with DNA encoding a novel human proteolipid, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and DNA encoding a novel human proteolipid will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-2394951