Isolated tyrosinase derived peptides and uses thereof

Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...

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4241931, 530328, G01N 3353, A61K 39385, A61K 3804

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active

058436880

ABSTRACT:
The invention relates to the identification of complexes of human leukocyte antigen molecules and tyrosinase derived peptides on the surfaces of abnormal cells. The therapeutic and diagnostic ramifications of this observation are the subject of the invention.

REFERENCES:
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Greenberg, Therapy of murine leukemia with cyclophosphamide and immune lyt-2+ cells: cytolytic T cells can mediate eradication of disseminated leukemia, J. Immunology, vol. 136, No. 5, p. 1917, column 2, 1st sentence of the 1st paragraph. Mar. 1986.
Ruppert et al., Multiple transcripts of the mouse tyrosinase gene are generated by alternative splicing, The EMBO J. vol. 7, No. 9, pp. 2715-2722, p. 2715, column 1, lines 5-7. Jun. 1988.
Brichard, et al, "The Tyrosinase Gene Codes for an Antigen Recognized by Autologous Cytolytic T Lymphocytes on HLA-A2 Melanomas", J. Exp. Med. 178: 489-495 (1993).
Coulie, et al, "Genes Coding For Tumor Antigens Recognized by Human Cytolytic T Lymphocytes", J. Immunotherapy 14: 104-109 (1993).
Slingluff, et al, "Recognition of Human Melanoma Cells by HLA-A2.1 Restricted Cytotoxic T Lymphocytes As Mediated By At Least Six Shared Peptide Epitopes", J. Immunol. 150(7): 2955-2963 (Apr. 1, 1993).
Barinaga, "Getting Some `Backbone`: How MHC Binds Peptides" Science 257: 880-881 (Aug. 14, 1992).
Wolfel, et al, "Lysis of Human Melanoma Cells by Autologous Cytolytic T Cells Clones", J. Exp. Med. 170: 797-810 (Sep. 1989).

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