N-phenyl-N'-thienylmethyl-bis-diamino-5-methylene-1,3-dioxane-4,

Details N-phenyl-N'-thienylmethyl-bis-diamino-5-methylene-1,3-dioxane-4, N-phenyl-N'-thienylmethyl-bis-diamino-5-methylene-1,3-dioxane-4,

1992-03-06

1993-01-05

Rotman, Alan L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C07D31906

Patent

active

051772191

ABSTRACT:
The compounds of the formula: ##STR1## wherein X, Y and Z are, independently, hydrogen, halogen, hydroxy, nitro, cyano, carboxyl, trifluoromethyl, phenyl, amino, mono and dialkylamino, C.sub.1 -C.sub.12 alkyl or C.sub.1 -C.sub.12 alkoxy; R.sup.1 represents hydrogen, C.sub.1 -C.sub.18 saturated or unsaturated alkyl, cycloalkyl, phenyl, benzyl or substituted phenyl or substituted benzyl where the substituents are C.sub.1 -C.sub.12 alkyl, or C.sub.1 -C.sub.12 alkoxy; R.sup.2 represents a substituted thienyl group where the substituents are, independently, the same as X, Y and Z; or a pharmaceutically acceptable salt thereof, are ACAT inhibitors.

REFERENCES:
patent: 4387105 (1983-06-01), De Vries et al.
patent: 4387106 (1983-06-01), De Vries et al.
J. Med. Chem. 29, 1131 (1986) De Vries et al.
Derwent Abstract 40365K.
Synthesis, pp. 317-320 (1989).
Chem.Abstract 71(23)112900r.

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