Substituted 3-(pyridinylamino)-indoles

Details Substituted 3-(pyridinylamino)-indoles Substituted 3-(pyridinylamino)-indoles

1991-04-17

1993-01-05

Fan, Jane T.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514318, 514212, 5142352, 514255, 546273, 546193, 546194, 546147, 546274, 546271, 540597, 544131, 544124, 544360, A61K 3144, C07D40112

Patent

active

051770881

ABSTRACT:
There are disclosed various compounds of the formula below, ##STR1## where R.sub.1, W, X, Y and Z are as defined in the specification; which are useful for alleviating various memory dysfunctions such as Alzheimer's disease, as modulators of neurotransmitter function such as serotonergic and adrenergic, and as such are useful as antidepressants, anxiolytics, atypical antipsychotics, antiemetics, and for the treatment of personality disorders such as obsessive compulsive disorders.

REFERENCES:
patent: 4970218 (1990-11-01), Effland et al.
Kwartler, J. Amer. Chem. Soc., 65, 1804-1806 (1943).
Vivona, J. Heterocyclic Chem., 16, 783-784 (1979).
"Indoles", Part II edited by J. Houlihan, Chapter VI, pp. 210-212 Wiley-Interscience (1972).

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