Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Patent
1991-09-11
1993-01-05
Fan, Jane T.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
514309, 544237, 546141, C07D21724
Patent
active
051770750
ABSTRACT:
The invention is selected, novel, and known analogs of isoquinolinones of the formula ##STR1## and pharmaceutically acceptable salts thereof; novel pharmaceutical compositions; and a method for enhancing the lethal effects for tumor cells to treatment having DNA damaging activity such as ionizing radiation or with chemotherapeutic agents.
REFERENCES:
patent: 3644366 (1972-02-01), Jeanmart et al.
patent: 3716542 (1973-02-01), Lenaers
patent: 3963716 (1976-06-01), Inoue et al.
patent: 4065456 (1977-12-01), Nakagawa
patent: 4282232 (1981-08-01), Agrawal
patent: 4581368 (1986-08-01), Ahmed
patent: 4596817 (1986-06-01), Ahmed
Chaplin et al., CA 110: 185547q.
Siemann et al., CA 101: 225914e.
Vershinina, CA 147720h.
G. E. Adams, et al., Chemotherapy, vol. 7, pp. 187-206, Plenum Press, New York, 1975.
G. E. Adams, et al., Biochem & Biophysic, Res. Comm. 12:473 (1963).
J. L. Foster & R. L. Wilson (Brit. J. Radiol., 46:234 (1973))
J. Asquith, et al., Rad. Res., 60:108 (1974).
Ben Hur, et al., Rad. Res., 97:546 (1984).
T. Kato, Y. Suzumura, M. Fukushima, Anticancer Res. 1988 8,239.
Abstract Saka 24.10.73 Otsuka Pharm KK.
Abstract Saka 07.08.74 Otsuka Pharm KK.
Abstract Saka 05.02.74 Otsuka Pharm KK.
Abstract Saka 05.02.74 Otsuka Pharm KK.
Derwent Abstract No. 89-057727/08.
CA106(25)207129b.
Synthesis, 1977, p. 43 J. Org. Chem., 29:2543 (1964) Not Previously Provided.
CA106(24):205279b Khim Geterotsikl Soedi, 1984, 1, p. 132 To be provided.
Suto Mark J.
Turner William R.
Werbel Leslie M.
Daignault Ronald A.
Fan Jane T.
Thierstein Joan
Warner-Lambert & Company
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