Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Hormones – e.g. – prolactin – thymosin – growth factors – etc.
Patent
1988-03-15
1991-11-26
Griffin, Ronald W.
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Hormones, e.g., prolactin, thymosin, growth factors, etc.
530324, 530350, A61K 3736, C07K 1300, C07K 1500, C07K 1700
Patent
active
050683179
ABSTRACT:
A sulfoxide of human growth hormone has been produced and characterized. The sulfoxide derivative arises from a selective oxidation of Met.sup.14. The sulfoxide exhibits full biological activity.
REFERENCES:
Houghten et al., Archives of Biochemistry and Biophysics 178, 350-355 (1977).
Teh et al., J. Biol. Chem., 262, 6472-6477 (1987).
Riggin et al., Analytical Biochemistry, 167, 199-209 (1987).
Becker Gerald W.
Riggin Ralph M.
Eli Lilly and Company
Griffin Ronald W.
Jones Joseph A.
Martens William C.
Whitaker Leroy
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