Furo[3,2-b]pyridines and thieno[3,2-b]pyridines as inhibitors of

Details Furo[3,2-b]pyridines and thieno[3,2-b]pyridines as inhibitors of Furo[3,2-b]pyridines and thieno[3,2-b]pyridines as inhibitors of

1993-03-29

1994-12-20

Dentz, Bernard

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514302, 546114, 546115, 548154, C07D491048, C07D49504, A61K 31435

Patent

active

053746350

ABSTRACT:
Compounds having the formula I: ##STR1## are inhibitors of leukotriene biosynthesis. These compounds are useful as anti-asthmatic, anti-allergic, anti-inflammatory, and cytoprotective agents. They are also useful in treating angina, cerebral spasm, glomemlar nephritis, hepatitis, endotoxemia, uveitis, and allograft rejection and in preventing the formation of atherosclerotic plaques.

REFERENCES:
patent: 4629733 (1986-12-01), Muller et al.
patent: 5034403 (1991-07-01), Effland et al.
patent: 5095031 (1992-03-01), Brooks et al.
patent: 5190968 (1993-03-01), Gillard et al.
Sheinkman et al. Chem Ab., vol. 67, 54017 (1967).
Biniecki et al. Chem Ab., vol. 98, 197936 (1983).
Pakula et al., Chem Ab., vol. 105, 190835 (1986).

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