Optics: measuring and testing – Sample – specimen – or standard holder or support – Fluid containers
Patent
1997-05-23
1999-12-28
Kim, Robert H.
Optics: measuring and testing
Sample, specimen, or standard holder or support
Fluid containers
356317, 356318, G01N 100
Patent
active
060088923
ABSTRACT:
A sample substrate for use in a fluorescence imaging system includes a rigid base with a specularly reflective surface, typically metal, on which is deposited a transparent coating layer. The coating layer has a thickness selected so that a particular fluorescence excitation wavelength, corresponding to a specified fluorescent constituent to be sought in sample material, has an optical path from the top of the coating layer to the reflecting surface in the base of substantially an odd multiple of one-quarter wavelength, so that the standing wave of the fluorescence excitation wavelength of light incident on the substrate has an antinode located at or near where sample material would be disposed on top of the coating layer. This maximizes fluorescence excitation of the sample on the reflective substrate. The transparent coating layer may be a dielectric material (e.g. silica) or may be a multilayer structure with a top layer of biologically active material for binding a specified sample constituent.
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Johnston Richard F.
Kain Robert C.
Marason Eric G.
Kim Robert H.
Molecular Dynamics, Inc.
Schneck David M.
Schneck Thomas
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