Method of preparing D-luciferin derivatives

Details Method of preparing D-luciferin derivatives Method of preparing D-luciferin derivatives

Filed on

1993-05-14

Date issued

1994-12-20

Examiner

Wityshyn, Michael G.

Patent Class

Chemistry: molecular biology and microbiology

SubClass

Measuring or testing process involving enzymes or...

SubSubClass

Involving luciferase

Other Related Categories

435 4, 435 25, 435 772, 435 23, 540469, 548178, 536 2626, 530330, C12Q 166, C12Q 100, A61K 3702, C07D27762

Type

Patent

Status

active

Patent number

053745345

Description

ABSTRACT:
A method of preparing a 6-substituted D-luciferin ester suitable for use in the determination of pesticides by a bioluminescence method. The 6-substituted D-luciferin esters, such as 6-D-luciferin acetate, are prepared in a liquid solvent containing N-acetyl imidazole with D-luciferin and recovering as the reaction product 6-D-luciferin acetate.

REFERENCES:
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patent: 4357420 (1982-11-01), Bostick et al.
patent: 4863689 (1989-09-01), Leong et al.
patent: 5035999 (1991-07-01), Geiger et al.
patent: 5098828 (1992-03-01), Geiger et al.
patent: 5200311 (1993-04-01), Charm et al.
Toya, Y. et al, "Improved synthetic methods of firefly luciferin derivatives for use in bioluminescent analysis of hydrolytic enzymes; carboxylic esterase and alkaline phosphatase", Bulletin of the Chemical Society Of Japan, vol. 65, No. 10, Oct. 1992 pp. 2604-2610.
Kamijo, T. et al, "1-acyl-3-substituted imidazolium salts as highly reactive acylating agents", Chemical And Pharmaceutical Bulletin, vol. 30, No. 10, Oct. 1992, pp. 4242-4244.

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