Substituted 2-aminomethylphenyl sulfamates

Details Substituted 2-aminomethylphenyl sulfamates Substituted 2-aminomethylphenyl sulfamates

1977-09-16

1978-09-12

Evans, Joseph E.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Recombinant or stably-transformed bacterium encoding one or...

260456A, A61K 31095, C07C14116

Patent

active

041138775

ABSTRACT:
Substituted 2-aminomethylphenyl sulfamates and pharmaceutically acceptable acid addition salts wherein the sulfamate group is N-substituted with up to 2 groups and the phenyl nucleus is further substituted by from 2 to 4 nuclear substituents which are useful as diuretics and saluretics are disclosed. The products may be prepared by reacting a N-protected substituted 2-aminomethylphenol with a substituted sulfamoyl chloride to generate an intermediate which is N-deblocked to give the compounds of this invention.

REFERENCES:
patent: 2839562 (1958-06-01), Wegler et al.
patent: 3082238 (1963-03-01), Dunbar
patent: 3560521 (1971-02-01), Milkowski et al.
patent: 3794734 (1974-02-01), Cragoe et al.
patent: 4029816 (1977-06-01), Cragoe et al.

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