Method for cleaving the peptide-resin bond in solid phase peptid

Details Method for cleaving the peptide-resin bond in solid phase peptid Method for cleaving the peptide-resin bond in solid phase peptid

1977-06-16

1978-09-12

Phillips, Delbert R.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

2601125S, 2601125LH, 2601125T, 2601125TR, C07C10352, C07G 700

Patent

active

041137132

ABSTRACT:
An improved process for cleaving peptides bound to a polymer by way of a benzylester linkage during solid phase peptide synthesis, the improvement comprising hydrogenolysis of said linkage by catalytic hydrogenation using a palladium (II) salt with a weak acid anion as the catalyst.

REFERENCES:
B. W. Erickson and R. B. Merrifield, The Proteins, 3rd ed., vol. 11, (1976).
Res. Group Peptide Chem., Hung. Aeat. Sci. Hung. (C.A. 80 83584u).
R. B. Merrifield, Advances in Enzymology, 32, 1969, 221-295.
J. M. Stewart and J. D. Young, Solid Phase Peptide Synthesis, 1969.
Sugasaw et al., (C.A. 81 152637y).
C. Birr., Justus Leibigs, (C.A. 80 48385h).

Affiliated with

Also associated with

Rating

Method for cleaving the peptide-resin bond in solid phase peptid does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Method for cleaving the peptide-resin bond in solid phase peptid, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method for cleaving the peptide-resin bond in solid phase peptid will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-2383553