HBsAG Particle composed of single polypeptide subunits and the p

Details HBsAG Particle composed of single polypeptide subunits and the p HBsAG Particle composed of single polypeptide subunits and the p

1976-03-08

1978-09-12

Meyers, Albert T.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

424 8, 424 12, 424 86, 424 89, 424177, A61K 3912, A61K 3942, C07G 700, G01N 3316

Patent

active

041137124

ABSTRACT:
Hepatitis B surface antigen particles composed of single polypeptide subunits having a molecular weight of about 55,000 dalton are prepared by heating hepatitis B surface antigen in isotonic sodium chloride solution at about neutral pH containing a surfactant capable of delipidation such as alkali-metal salts of bile acids or of lauroylsarcosinic acid, or poloxyethylene alkylphenol containing an average oxyethylene of 7 to 10 molecules, or polyoxyethylene sorbitan monoalkylester containing an average oxyethylene of 20 molecules.
A uniform hepatitis B surface antigen particle thus obtained has a spherical form 18 to 22 nm in diameter with an empty core, a molecular weight of about 2,200,000 dalton, and the characteristic of low toxicity.
This hepatitis B surface antigen particle is useful for the preparation of vaccines, as a standard antigen reagent for testing hepatitis B surface antigen and the antibody, and as an antigen for immunizing animals to obtain a highly specific and strong antibody.

REFERENCES:
Manual for the Handling of App'l. for Pats., Designs & T.M. Throughout the World, Octrooibureau Los en Stigter, Amsterdam, vol. 2, Supp'l. No. 27, Jul. 1972, pp. 1-3 & 7.
Gerin, J. of Virol., vol. 4, 1969, pp. 763-768.
Barker, J. of Virol, vol. 14, 1974, pp. 1552-1558.
Dreesman, The Amer. J. of the Med. Sci., vol. 270, No. 1, Jul.-Aug., 1975, pp. 123-129.

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