Organic compounds -- part of the class 532-570 series – Organic compounds – Amino nitrogen containing
Patent
1999-03-26
1999-12-28
O'Sullivan, Peter
Organic compounds -- part of the class 532-570 series
Organic compounds
Amino nitrogen containing
564285, 564287, 564363, C07G20988
Patent
active
06008412&
ABSTRACT:
The present invention relates to processes for resolving N-methyl-3(R,S)-hydroxy-3-phenylpropylamine and N,N-dimethyl-3 (R,S) -hydroxy-3-phenylpropylamine with the isomers of mandelic acid and the resulting salts.
REFERENCES:
patent: 4765826 (1988-08-01), Van Heertum et al.
patent: 5527821 (1996-06-01), Willman et al.
Robertson, D. W., et al., Absolute Configurations and Pharmaceutical Activities of the Optical Isomers of Fluoxetine, A Selective Serotonin-Uptake Inhibitor Journal of Medicinal Chemistry, vol. 31, No. 7, Jul. 1, 1988, pp. 1412-1417.
Eli Lilly and Company
O'Sullivan Peter
Stemerick David M.
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