Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1998-01-20
1999-12-28
Raymond, Richard L.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
5142272, 5142278, 5142288, 5142355, 5142358, 514255, 514256, 514275, 514318, 514320, 514321, 514323, 514326, 514327, 544 54, 544 55, 544 581, 544 59, 544 88, 544129, 544130, 544316, 544319, 544330, 544332, 544360, 546188, 546193, 546194, 546197, 546201, 546202, 546208, 546209, 546210, 546213, 546316, A61K 31445, A61K 31505, C07D21176, C07D40104
Patent
active
060082232
ABSTRACT:
Compounds of formula I ##STR1## wherein Q.sup.1, Q.sup.2, Q.sup.3, and Q.sup.4 have any of the meanings given in the specification, their N-oxides, and their pharmaceutically acceptable salts are nonpeptide antagonists of SP and NKA are useful for the treatment of asthma, etc. Also disclosed are pharmaceutical compositions, processes for preparing the compounds of formula I and intermediates.
REFERENCES:
patent: 4782061 (1988-11-01), Kruse et al.
patent: 5236921 (1993-08-01), Emonds-Alt et al.
patent: 5521199 (1996-05-01), Jacobs et al.
patent: 5534525 (1996-07-01), Miller
patent: 5559131 (1996-09-01), Miller
patent: 5559132 (1996-09-01), Miller
patent: 5567700 (1996-10-01), Miller
patent: 5576333 (1996-11-01), Miller
patent: 5589489 (1996-12-01), Shenvi et al.
patent: 5602138 (1997-02-01), Miller
patent: 5635509 (1997-06-01), Jacobs et al.
patent: 5654299 (1997-08-01), Shenvi et al.
A. Graham et al., "Isolation and Characterisation of the Human Lung NK-2 Receptor Gene Using Rapid Amplification of cDNA Ends", Biochemical and Biophysical Research Communications, (1991), vol. 177, No. 1, 8-16.
X. Emonds-Alt et al., "Pharmacological Profile and Chemical Synthesis of SR 48968, a Non-Peptide Antagonist of the Neurokinin A (NK2) Receptor", Biorganic & Medicinal Chemistry Letters, (1993), vol. 3, No. 5, 925-930.
D. Aharony et al., "Pharmacologic Characterization of the Novel Ligand [4,5-3H-LEU9]Neurokinin-A Binding to NK-2 Receptors on Hamster Urinary Bladder Membranes", Neuropeptides, (1992), 23, 121-130.
M. Needham et al., "LCR/MEL: A Versatile System for High-Level Expression of Heterologous Proteins in Erythroid Cells", Nucleic Acids Research, (1992), vol. 20, No. 5, 997-1003.
M. Ichinose et al., "Protection against bradykinin-induced bronchoconstriction in asthmatic patients by receptor antagonist", The Lancet, (1992), vol. 340, 1248-1251.
Bernstein Peter R.
Miller Scott C.
Person Richard V.
Raymond Richard L.
Zeneca Limited
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